Developing new materials to help heal damaged nerves
Official title: Ionically Conductive Polymeric Biomaterials and Grafts for Nerve Regeneration
Funded at University of Nebraska Medical Center · NIH-11302512 · Data updated 2026-11-12
This study is exploring new ways to help people with peripheral nerve injuries heal better by using special grafts that support nerve growth, along with electrical stimulation and a helpful chemical, to improve recovery after surgery.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Medical Center NIH-funded |
| Lab location | 1 site (Omaha, United States) |
| Project start | December 27, 2023 |
| Project end | March 12, 2029 |
| Funding year | 2025 |
| Award (this year) | $360,118 |
| NIH project number | 7R01NS134604-03 |
| Project ID | NIH-11302512 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced significant peripheral nerve injuries requiring surgical intervention.
✕Less likely to help
Patients with minor nerve injuries that do not require surgical repair may not benefit from this research.
What this research studies
This research focuses on improving treatments for peripheral nerve injuries, which can significantly impact patients' quality of life. The team is working on creating innovative grafts that can better support nerve regeneration, particularly in cases where there are large gaps in the nerve. By combining electrical stimulation and a chemical agent called 4-aminopyridine, the researchers aim to enhance the healing process and improve outcomes for patients undergoing nerve repair surgeries. The approach involves using biodegradable materials that can conduct electricity and support nerve growth, potentially leading to more effective treatments.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients with severe nerve injuries, improving their recovery and quality of life.
How similar studies have gone: Previous research has shown promise in using electrical and chemical stimulation for nerve repair, suggesting that this combined approach could be effective.
Where this research is happening
-
University of Nebraska Medical Center
Omaha, United States Active
Researchers
- Principal investigator: Kumbar, Sangamesh Gurappa — University of Nebraska Medical Center
- Study coordinator: Kumbar, Sangamesh Gurappa
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.