Developing a new method for highly sensitive blood tests to detect diseases like pancreatic cancer.
Official title: High Throughput Digital Droplet Assays for Ultrasensitive Multimodal (DNA, RNA, and Protein) Diagnostics
Funded at University of Pennsylvania · NIH-11051864 · Data updated 2026-11-12
This study is testing a new way to quickly and accurately detect DNA, RNA, and proteins in blood samples using tiny droplets and a special chip, making it easier for doctors to diagnose hard-to-detect diseases with just a smartphone camera.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | March 7, 2024 |
| Project end | February 28, 2027 |
| Funding year | 2025 |
| Award (this year) | $383,922 |
| NIH project number | 5R33CA287135-02 |
| Project ID | NIH-11051864 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with suspected difficult-to-diagnose conditions, such as pancreatic cancer.
✕Less likely to help
Patients with well-established or easily diagnosable conditions may not receive significant benefits from this research.
What this research studies
This research focuses on creating advanced digital assays that can perform millions of tests simultaneously in tiny droplets, allowing for ultra-sensitive detection of DNA, RNA, and proteins in blood samples. By utilizing a novel microelectronic and microfluidic chip, the team aims to make these assays practical for clinical use, significantly improving the speed and sensitivity of diagnostics. The technology leverages a conventional cell phone camera to analyze the results, making it more accessible for healthcare settings. This approach could transform how difficult-to-diagnose diseases are identified and monitored.
Why it matters
Potential benefit: If successful, this research could lead to earlier and more accurate diagnoses of challenging diseases, potentially improving patient outcomes.
How similar studies have gone: Previous research has shown promise in using digital assays for molecular diagnostics, indicating a strong potential for success with this innovative approach.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Issadore, David Aaron — University of Pennsylvania
- Study coordinator: Issadore, David Aaron
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.