Developing a new method for highly sensitive blood tests to detect diseases like pancreatic cancer.
High Throughput Digital Droplet Assays for Ultrasensitive Multimodal (DNA, RNA, and Protein) Diagnostics
This study is testing a new way to quickly and accurately detect DNA, RNA, and proteins in blood samples using tiny droplets and a special chip, making it easier for doctors to diagnose hard-to-detect diseases with just a smartphone camera.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11051864 on NIH RePORTER |
What this research studies
This research focuses on creating advanced digital assays that can perform millions of tests simultaneously in tiny droplets, allowing for ultra-sensitive detection of DNA, RNA, and proteins in blood samples. By utilizing a novel microelectronic and microfluidic chip, the team aims to make these assays practical for clinical use, significantly improving the speed and sensitivity of diagnostics. The technology leverages a conventional cell phone camera to analyze the results, making it more accessible for healthcare settings. This approach could transform how difficult-to-diagnose diseases are identified and monitored.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with suspected difficult-to-diagnose conditions, such as pancreatic cancer.
Not a fit: Patients with well-established or easily diagnosable conditions may not receive significant benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier and more accurate diagnoses of challenging diseases, potentially improving patient outcomes.
How similar studies have performed: Previous research has shown promise in using digital assays for molecular diagnostics, indicating a strong potential for success with this innovative approach.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Issadore, David Aaron — University of Pennsylvania
- Study coordinator: Issadore, David Aaron
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.