Detecting gene changes in leukemia cells using advanced technology
Official title: Large scale single-cell gene rearrangement detection with a microfluidic device
Funded at Loma Linda University · NIH-10910039 · Data updated 2026-11-12
This study is looking at a new way to better understand and treat acute myeloid leukemia (AML) by using a special device to closely examine individual leukemia cells, which could help doctors choose the best treatment for patients and improve their chances of recovery.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Loma Linda University NIH-funded |
| Lab location | 1 site (Loma Linda, UNITED STATES) |
| Project start | July 1, 2020 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $344,232 |
| NIH project number | 5R01CA251848-06 |
| Project ID | NIH-10910039 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults diagnosed with acute myeloid leukemia who require improved diagnostic and treatment strategies.
✕Less likely to help
Patients with other types of leukemia or those who do not have acute myeloid leukemia may not benefit from this research.
What this research studies
This research focuses on improving the diagnosis and treatment of acute myeloid leukemia (AML) by utilizing a cutting-edge microfluidic device to analyze individual leukemia cells. The approach, known as S-CytoSeq, allows for the detailed profiling of mRNA abnormalities, including fusion genes and alternative splicing, which are crucial for understanding the disease at a molecular level. By generating a more accurate cytogenetic profile, this research aims to enhance risk stratification and treatment selection for AML patients, potentially leading to better outcomes.
Why it matters
Potential benefit: If successful, this research could lead to more precise and effective treatment options for patients with acute myeloid leukemia.
How similar studies have gone: Previous research has shown promise in using single-cell sequencing technologies for cancer diagnostics, indicating that this approach could be effective.
Where this research is happening
-
Loma Linda University
Loma Linda, United States Active
Researchers
- Principal investigator: Zhong, John — Loma Linda University
- Study coordinator: Zhong, John
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.