Detecting gene changes in leukemia cells using advanced technology
Large scale single-cell gene rearrangement detection with a microfluidic device
This study is looking at a new way to better understand and treat acute myeloid leukemia (AML) by using a special device to closely examine individual leukemia cells, which could help doctors choose the best treatment for patients and improve their chances of recovery.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Loma Linda University NIH-funded |
| Lab location | 1 site (Loma Linda, UNITED STATES) |
| Project ID | NIH-10910039 on NIH RePORTER |
What this research studies
This research focuses on improving the diagnosis and treatment of acute myeloid leukemia (AML) by utilizing a cutting-edge microfluidic device to analyze individual leukemia cells. The approach, known as S-CytoSeq, allows for the detailed profiling of mRNA abnormalities, including fusion genes and alternative splicing, which are crucial for understanding the disease at a molecular level. By generating a more accurate cytogenetic profile, this research aims to enhance risk stratification and treatment selection for AML patients, potentially leading to better outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults diagnosed with acute myeloid leukemia who require improved diagnostic and treatment strategies.
Not a fit: Patients with other types of leukemia or those who do not have acute myeloid leukemia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more precise and effective treatment options for patients with acute myeloid leukemia.
How similar studies have performed: Previous research has shown promise in using single-cell sequencing technologies for cancer diagnostics, indicating that this approach could be effective.
Where this research is happening
Loma Linda, UNITED STATES
- Loma Linda University — Loma Linda, United States (Active)
Researchers
- Principal investigator: Zhong, John — Loma Linda University
- Study coordinator: Zhong, John
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.