Detecting early changes in lung structure using advanced x-ray imaging
Official title: Speckle x-ray imaging: detecting early changes in lung microstructure
Funded at University of Pennsylvania · NIH-11007256 · Data updated 2026-11-12
This study is testing a new imaging tool that helps doctors spot early changes in the tiny air sacs in your lungs, which is especially important for people getting proton therapy, so they can catch problems sooner and provide better treatment.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | February 1, 2023 |
| Project end | November 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $543,644 |
| NIH project number | 5R01HL166236-03 |
| Project ID | NIH-11007256 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include patients undergoing proton therapy or those at risk of developing lung fibrosis due to radiation exposure.
✕Less likely to help
Patients with pre-existing severe lung conditions unrelated to radiation exposure may not benefit from this research.
What this research studies
This research focuses on developing a new imaging tool that can detect early changes in the microstructure of the lungs, particularly the alveoli, which are crucial for proper lung function. By utilizing advanced x-ray darkfield imaging techniques, the study aims to improve the sensitivity of lung diagnostics, allowing for earlier intervention in conditions like radiation-induced lung fibrosis. The approach seeks to provide a more effective method for monitoring lung health, especially in patients undergoing proton therapy. This could lead to better-targeted treatments and improved patient outcomes.
Why it matters
Potential benefit: If successful, this research could lead to earlier diagnosis and treatment of lung conditions, potentially improving the quality of life for patients receiving radiation therapy.
How similar studies have gone: Other research has shown promise in using advanced imaging techniques for early detection of lung issues, suggesting that this approach could be effective.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Noël, Peter B — University of Pennsylvania
- Study coordinator: Noël, Peter B
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.