Deep profiling of sleep and symptoms in teens with psychosis-spectrum issues
Official title: Deep phenotyping of sleep and symptoms in adolescents with psychosis-spectrum conditions
Funded at Emma Pendleton Bradley Hospital · NIH-11388243 · Data updated 2026-11-12
Teenagers with psychosis-spectrum symptoms may experience sleep problems that relate to how their symptoms change over a few weeks, helping guide future care.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emma Pendleton Bradley Hospital NIH-funded |
| Lab location | 1 site (Riverside, UNITED STATES) |
| Project start | July 1, 2026 |
| Project end | June 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $398,669 |
| NIH project number | 1R21MH142950-01A1 |
| Project ID | NIH-11388243 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adolescents aged 14-17 with psychosis-spectrum symptoms or at high risk, who can complete daily assessments and wear sleep-monitoring devices.
✕Less likely to help
Teens without psychosis-spectrum symptoms or those unable to participate in daily assessments may not benefit.
What this research studies
This project follows 40 adolescents aged 14-17 to track daily mood and sleep over 3 weeks, using both self-reports and objective sleep measures, along with stress assessments. By looking at how sleep patterns, psychosis symptoms, and stress interact over time, the study aims to uncover mechanisms that could inform new treatments. The findings could point to timing and targets for interventions to improve sleep and reduce peak symptom days in youth at risk for psychosis. Participants will contribute multiple daily data points and provide inputs that help researchers understand personalized sleep–symptom links.
Why it matters
Potential benefit: If successful, the study could guide personalized sleep-focused strategies to reduce psychosis-related symptoms in adolescents.
How similar studies have gone: Previous work shows sleep is linked to psychosis risk, but dense daily measurements in youth are limited and this study aims to fill that gap.
Where this research is happening
-
Emma Pendleton Bradley Hospital
Riverside, United States Active
Researchers
- Principal investigator: Saletin, Jared Meyer — Emma Pendleton Bradley Hospital
- Study coordinator: Saletin, Jared Meyer
Related research
Other NIH-funded projects on the same topics.
-
Psychosis in diverse settings across the world
This project studies how psychotic disorders show up and respond to treatment in adults with diverse backgrounds, including populations in Africa, the Caribbean, and other Global South settings.
-
Psychosis in Diverse Settings: Understanding Symptoms and Treatment Across Global South
A human-facing study will look at how psychotic disorders present and respond to treatment in adults from Africa, the Caribbean, and other Global South settings, using genetic and clinical data.
-
A new online brain-scan-style tool to spot early psychosis risk
A new online-based set of tasks and a computer model aims to identify people at high risk for developing psychosis earlier and more accurately.
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Genetic clues for early-onset psychosis in Latino youth
This project looks at the genes of young people with early-onset psychosis and compares them with similar youths without psychosis to find genetic factors that contribute to the illness.
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Biomarkers to tailor rehab for Veterans with schizophrenia
A clinician-scientist is developing a brain-based biomarker to guide personalized rehabilitation for Veterans with schizophrenia.
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Computational analysis of facial expression in early psychosis
Aims to develop computer-based measures of facial expression in people at risk for or with schizophrenia to help track symptoms and guide future trials.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.