Decoding heart cell subtypes to understand and treat heart failure
Official title: Integrative Machine Learning Approaches to Decode Cardiomyocyte Subtype Dynamics in Heart Failure
Funded at Beckman Research Institute/city of Hope · NIH-11428566 · Data updated 2026-11-12
A patient-facing look at a grant that aims to map heart muscle cell types to uncover why high blood pressure can lead to heart failure and guide better therapies.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beckman Research Institute/city of Hope NIH-funded |
| Lab location | 1 site (Duarte, United States) |
| Project start | August 15, 2026 |
| Project end | April 30, 2031 |
| Funding year | 2026 |
| Award (this year) | $697,806 |
| NIH project number | 1R01HL187901-01 |
| Project ID | NIH-11428566 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with hypertension and evolving or established heart failure who consent to donate tissue samples or participate in related studies.
✕Less likely to help
Patients without hypertension or heart failure or those who do not participate in any sample collection or data-sharing activities may not directly benefit.
What this research studies
This project uses advanced genetic and genomic techniques to study heart tissue at the level of individual cells and nuclei, focusing on how different cardiomyocyte subtypes behave as heart failure develops. Researchers will analyze existing and new data from heart samples to map changes in gene activity and chromatin accessibility during disease progression. The goal is to identify new targets and approaches that could prevent or reverse the faulty heart remodeling caused by high blood pressure. The work involves collaboration across computational biology and heart disease experts to translate findings toward future treatments.
Why it matters
Potential benefit: If successful, the research could reveal new intervention points to slow or stop heart failure progression in patients with hypertension.
How similar studies have gone: Similar multi-omics approaches have yielded new insights in cardiac biology, with growing evidence that cell-type-specific changes drive disease.
Where this research is happening
-
Beckman Research Institute/city of Hope
Duarte, United States Active
Researchers
- Principal investigator: Ren, Di — Beckman Research Institute/city of Hope
- Study coordinator: Ren, Di
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.