CSE and hydrogen sulfide: new clues about aging and blood vessels
Official title: Cystathionine Gamma Lyase (CSE) and Hydrogen Sulfide Regulation of Vascular Aging
Funded at Louisiana State Univ Hsc Shreveport · NIH-11379113 · Data updated 2026-11-12
A doctor-scientist at LSU Health Shreveport is studying how a molecule called CSE and hydrogen sulfide affect aging blood vessels and heart-related health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Louisiana State Univ Hsc Shreveport NIH-funded |
| Lab location | 1 site (Shreveport, United States) |
| Project start | February 1, 2018 |
| Project end | June 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $196,585 |
| NIH project number | 5P20GM121307-09 |
| Project ID | NIH-11379113 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates would be individuals affected by age-related vascular issues or those with conditions linked to aging and vascular aging, who may contribute samples or participate in future studies.
✕Less likely to help
This grant is primarily basic and preclinical; it may not offer direct benefits to any individual participant during the grant period.
What this research studies
As people age, their blood vessels often don’t work as well, which can raise the risk of heart and brain diseases. This grant will look at how CSE and hydrogen sulfide signaling influence endothelial cells and vascular remodeling in aging, aiming to uncover new molecular mechanisms. The work uses laboratory studies with aging-related models to understand how reduced CSE/H2S might lower nitric oxide availability and worsen vascular function over time. The team plans to use two specific aims to identify pathways and test how changes in CSE/H2S affect aging blood vessels, with the goal of generating data for future, larger grants.
Why it matters
Potential benefit: If successful, this research could reveal targets to preserve vascular health as people age, potentially reducing cardiovascular and cognitive risks.
How similar studies have gone: Previous studies in vascular aging have shown that signaling molecules like hydrogen sulfide influence vessel function, supporting the potential of this approach.
Where this research is happening
-
Louisiana State Univ Hsc Shreveport
Shreveport, United States Active
Researchers
- Principal investigator: Kolluru, Gopi K — Louisiana State Univ Hsc Shreveport
- Study coordinator: Kolluru, Gopi K
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.