Creating stem cell-based vascular grafts for emergency surgeries
Readily Available Stem Cell-Based Vascular Grafts for Emergent Surgical Care
This study is working on a new type of blood vessel replacement made from stem cells to help people who have serious injuries, like those from car accidents, so they can get better care quickly and safely.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10841794 on NIH RePORTER |
What this research studies
This research focuses on developing a new type of vascular graft made from stem cells to help patients who have suffered severe vascular trauma, such as from traffic accidents or blast injuries. The approach involves creating acellular tissue-engineered vascular grafts (TEVGs) that can be readily available for emergency surgical care. By using human vascular smooth muscle cells, the researchers aim to overcome the limitations of traditional grafts, which can be difficult to access or prone to infection. The goal is to provide a safer and more effective alternative for patients needing vascular repair.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients who have experienced severe vascular trauma, particularly those with limited access to traditional graft sources.
Not a fit: Patients with vascular injuries that do not require grafting or those who are not candidates for surgical intervention may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a readily available and safer option for vascular repair in trauma patients, potentially improving surgical outcomes.
How similar studies have performed: While the concept of using tissue-engineered vascular grafts is being explored, this specific approach using stem cells for emergency care is relatively novel and has not been extensively tested.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Qyang, Yibing — Yale University
- Study coordinator: Qyang, Yibing
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.