Creating specialized probes to detect specific sugars linked to diseases
Engineered probes for sialoglycan detection
['FUNDING_R01'] · VANDERBILT UNIVERSITY · NIH-10653008
This study is working on creating special proteins that can easily find certain sugars linked to diseases like cancer and autoimmune disorders, helping doctors better detect these conditions.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VANDERBILT UNIVERSITY (nih funded) |
| Locations | 1 site (Nashville, UNITED STATES) |
| Trial ID | NIH-10653008 on ClinicalTrials.gov |
What this research studies
This research focuses on developing engineered proteins that can effectively detect sialoglycans, which are sugars that can be difficult to identify with traditional methods. By utilizing naturally-occurring proteins that bind to these sugars, the team aims to create new probes that can specifically target and recognize certain sialoglycans associated with diseases like cancer and autoimmune disorders. The approach involves advanced protein engineering techniques to enhance the specificity and affinity of these probes, making them more effective for clinical applications.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with cancers or autoimmune diseases that may be linked to specific sialoglycan markers.
Not a fit: Patients without any autoimmune conditions or cancers may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic tools for detecting diseases associated with specific sialoglycans, potentially enhancing early detection and treatment options for patients.
How similar studies have performed: Previous research has shown promise in using engineered proteins for glycan detection, indicating that this approach could be a significant advancement in the field.
Where this research is happening
Nashville, UNITED STATES
- VANDERBILT UNIVERSITY — Nashville, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: IVERSON, T M — VANDERBILT UNIVERSITY
- Study coordinator: IVERSON, T M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Autoimmune Diseases, autoimmune disorder, autoimmunity disease, Bacterial Infections, bacteria infection