Creating programmable enzymes to edit proteins in cells
Official title: Engineering programmable enzymes for proteome editing
Funded at Dana-Farber Cancer Inst · NIH-10686522 · Data updated 2026-11-12
This study is exploring new ways to create special enzymes that can be turned on or off by antibodies, which could help scientists better control how proteins work in our cells and lead to improved treatments for diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dana-Farber Cancer Inst NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2026 |
| Funding year | 2023 |
| Award (this year) | $1,602,000 |
| NIH project number | 1DP2GM154013-01 |
| Project ID | NIH-10686522 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions that involve protein dysfunction or require targeted protein manipulation.
✕Less likely to help
Patients with conditions unrelated to protein function or those who do not require targeted protein therapies may not benefit from this research.
What this research studies
This research focuses on developing innovative enzymes that can be activated by specific interactions with antibodies. By engineering these enzymes to switch between inactive and active states based on target binding, the project aims to enhance our ability to manipulate proteins within cells. This approach could lead to new methods for controlling protein functions, constructing biosensors, and modifying cell signaling pathways. Patients may benefit from advancements in treatments that target specific proteins involved in various diseases.
Why it matters
Potential benefit: If successful, this research could lead to more precise therapies that target specific proteins, improving treatment outcomes for patients with various conditions.
How similar studies have gone: Other research has shown promise in using engineered enzymes for targeted protein manipulation, indicating a potential for success in this novel approach.
Where this research is happening
-
Dana-Farber Cancer Inst
Boston, United States Active
Researchers
- Principal investigator: Zhou, Xin — Dana-Farber Cancer Inst
- Study coordinator: Zhou, Xin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.