Creating mutant models in frogs to study human diseases
Xenopus Mutant Resource
This study is creating special frog models to help scientists learn more about human diseases by using a cool gene-editing tool, so they can better understand how these diseases work and find new ways to treat them.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Marine Biological Laboratory NIH-funded |
| Lab location | 1 site (Woods Hole, United States) |
| Project ID | NIH-10933890 on NIH RePORTER |
What this research studies
This research focuses on generating and characterizing mutants of the amphibian Xenopus, which are linked to key genes associated with human diseases. Using advanced CRISPR-Cas gene editing techniques, the project aims to develop precise models that can help researchers better understand various diseases. The initiative includes collaboration with other researchers to characterize existing mutants and create new ones, as well as developing transgenic lines for more targeted genome editing. These efforts will provide valuable resources for the biomedical research community.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals interested in genetic diseases or those who may benefit from advancements in biomedical research related to human health.
Not a fit: Patients with conditions unrelated to the genetic models being studied in Xenopus may not receive any direct benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new models that enhance our understanding of human diseases and potentially improve treatment strategies.
How similar studies have performed: Other research utilizing CRISPR-Cas technology in model organisms has shown promising results, indicating that this approach has the potential for significant advancements in understanding human diseases.
Where this research is happening
Woods Hole, United States
- Marine Biological Laboratory — Woods Hole, United States (Active)
Researchers
- Principal investigator: Horb, Marko E — Marine Biological Laboratory
- Study coordinator: Horb, Marko E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.