Xenopus Mutant Resource for human-disease models
Official title: Xenopus Mutant Resource
Funded at Marine Biological Laboratory · NIH-11370708 · Data updated 2026-11-12
This NIH grant helps the Marine Biological Laboratory create and share Xenopus frog models of human diseases, using CRISPR to build precise genetic mutations and new lines for genome editing.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Marine Biological Laboratory NIH-funded |
| Lab location | 1 site (Woods Hole, United States) |
| Project start | July 15, 2020 |
| Project end | June 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $769,186 |
| NIH project number | 5R24OD030008-07 |
| Project ID | NIH-11370708 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not applicable to direct patient participation; this is a model-organism resource that supports disease research.
✕Less likely to help
No direct patient involvement or intervention in this grant.
What this research studies
Researchers will generate and characterize Xenopus mutants in genes linked to human disease and develop transgenic lines to improve genome editing. The project aims to provide ready-to-use disease models and resources for the broader biomedical community. It involves collaboration with other Xenopus researchers, breeding and maintaining mutants, and advancing site-specific genome editing techniques to enhance disease modeling.
Why it matters
Potential benefit: If successful, patients may benefit indirectly through better animal models that accelerate understanding and treatment development for human diseases.
How similar studies have gone: Similar Xenopus models and CRISPR approaches have advanced in the field, with growing community resources and tools.
Where this research is happening
-
Marine Biological Laboratory
Woods Hole, United States Active
Researchers
- Principal investigator: Horb, Marko E — Marine Biological Laboratory
- Study coordinator: Horb, Marko E
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.