Creating Frog Models for Human Diseases
Xenopus Mutant Resource
This project creates special frog models using gene editing to help scientists better understand and find new treatments for human diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Marine Biological Laboratory NIH-funded |
| Lab location | 1 site (Woods Hole, United States) |
| Project ID | NIH-11134694 on NIH RePORTER |
What this research studies
This project focuses on creating and studying genetically modified frogs, called Xenopus, to serve as models for various human diseases. Researchers use advanced gene-editing tools like CRISPR-Cas to precisely change genes in these frogs, mimicking genetic conditions found in people. The goal is to develop a wide range of frog models that the broader scientific community can use to explore disease mechanisms and test potential therapies. By studying these models, scientists hope to gain new insights into how human diseases develop and progress.
Who could benefit from this research
Good fit: This foundational research does not directly involve human patients, but future studies building on these models could seek individuals with specific genetic conditions.
Not a fit: Patients will not directly receive treatment or participate in this specific project, as it focuses on developing animal models for research.
Why it matters
Potential benefit: If successful, this work could lead to a better understanding of human diseases and accelerate the discovery of new treatments by providing valuable research tools.
How similar studies have performed: Using animal models like frogs to understand human diseases is a well-established approach in biomedical research, with many past successes in uncovering disease mechanisms.
Where this research is happening
Woods Hole, United States
- Marine Biological Laboratory — Woods Hole, United States (Active)
Researchers
- Principal investigator: Horb, Marko E — Marine Biological Laboratory
- Study coordinator: Horb, Marko E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.