Creating advanced cell-based devices that can detect and respond to diseases
A synthetic signaling pathway engineering platform for creating precision cell-based sense-and-response devices
This study is working on creating smart cells that can sense when something is wrong in the body and automatically take action to help, making treatments safer and more effective for people with different health issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rice University NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10907415 on NIH RePORTER |
What this research studies
This research focuses on engineering synthetic signaling pathways in human cells to develop dynamic cell-based therapeutic devices. These devices aim to autonomously detect disease signals and respond with appropriate therapeutic actions. By mimicking natural cell signaling processes, the project seeks to enhance the safety and effectiveness of cell therapies. The approach involves creating systems that can quickly and accurately respond to changes in their environment, potentially leading to more effective treatments for various conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with conditions that could benefit from advanced cell therapies, such as autoimmune diseases or cancers.
Not a fit: Patients with conditions that do not involve cellular signaling or do not require cell-based therapies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies that autonomously detect and treat diseases, improving patient outcomes.
How similar studies have performed: While the approach of engineering synthetic signaling pathways is innovative, similar research has shown promise in developing cell-based therapies, indicating potential for success.
Where this research is happening
Houston, United States
- Rice University — Houston, United States (Active)
Researchers
- Principal investigator: Bashor, Caleb — Rice University
- Study coordinator: Bashor, Caleb
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.