Creating advanced brain models using human stem cells
Official title: Human PSC-based cortical organoid and assembloid systems integrating pericyte and microglial lineages and signals
Funded at Sloan-Kettering Inst Can Research · NIH-10983330 · Data updated 2026-11-12
This study is working on creating tiny, 3D models of the human brain using special stem cells to help us learn more about how the brain develops and how diseases affect it, which could lead to better treatments for brain-related conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | November 8, 2023 |
| Project end | October 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $600,540 |
| NIH project number | 5R01MH135403-02 |
| Project ID | NIH-10983330 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with neurological conditions or those interested in the biological mechanisms of brain development.
✕Less likely to help
Patients with conditions unrelated to brain development or neurological disorders may not benefit from this research.
What this research studies
This research focuses on developing three-dimensional brain organoids from human pluripotent stem cells to better understand brain development and diseases. By generating over 50 distinct human cell types, the project aims to create more accurate models of both the Central and Peripheral Nervous Systems. The researchers are enhancing these models by integrating signals from non-neural cells, such as vascular and immune cells, to improve the representation of critical brain cell types. This innovative approach could lead to more effective treatments for neurological disorders.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding and treating various brain disorders.
How similar studies have gone: Other research has shown promise in using similar 3D organoid models to study brain diseases, indicating a potential for success in this novel approach.
Where this research is happening
-
Sloan-Kettering Inst Can Research
New York, United States Active
Researchers
- Principal investigator: Studer, Lorenz P. — Sloan-Kettering Inst Can Research
- Study coordinator: Studer, Lorenz P.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.