Creating a new instrument to determine protein structures using superfluid helium droplets
Official title: Cryostat for generation of superfluid helium droplets
Funded at Oregon State University · NIH-11100488 · Data updated 2026-11-12
This study is exploring a new way to look at the tiny structures of proteins by using special techniques that cool them down and help us see them more clearly, which could lead to better treatments for health conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon State University NIH-funded |
| Lab location | 1 site (Corvallis, United States) |
| Project start | August 11, 2023 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $62,162 |
| NIH project number | 3R01GM149881-02S1 |
| Project ID | NIH-11100488 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for benefiting from this research include individuals with conditions related to protein misfolding or dysfunction, such as certain genetic disorders or diseases like Alzheimer's.
✕Less likely to help
Patients with conditions unrelated to protein structure or function may not receive direct benefits from this research.
What this research studies
This research focuses on developing an innovative instrument that combines electron diffraction with mass spectrometry to analyze the atomic structures of proteins. By embedding proteins in superfluid helium droplets, the study aims to cool samples effectively and align them for precise measurements. The approach utilizes a pulsed electric field and laser technology to define the orientation of proteins, allowing for detailed electron diffraction patterns to be collected. This method could enhance our understanding of protein structures, which is crucial for various biological and medical applications.
Why it matters
Potential benefit: If successful, this research could lead to significant advancements in the understanding of protein structures, potentially impacting drug development and disease treatment.
How similar studies have gone: Other research has shown promise in using advanced mass spectrometry techniques for protein analysis, indicating that this approach could be a valuable addition to the field.
Where this research is happening
-
Oregon State University
Corvallis, United States Active
Researchers
- Principal investigator: Kong, Wei — Oregon State University
- Study coordinator: Kong, Wei
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.