Creating a 3D model to study fluid flow in the eye's drainage system.
TM/SC-interface-on-a-chip for mechanistic studies of outflow regulation.
This study is creating a special 3D model of parts of the eye that help control fluid drainage, so researchers can learn more about how these areas work and how they might be linked to conditions like glaucoma, ultimately aiming to find better treatments for people dealing with eye pressure problems.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Upstate Medical University NIH-funded |
| Lab location | 1 site (Syracuse, United States) |
| Project ID | NIH-11080368 on NIH RePORTER |
What this research studies
This research focuses on developing a novel 3D model that mimics the trabecular meshwork and Schlemm's canal interface, which are crucial for regulating fluid drainage in the eye. By creating this advanced model, researchers aim to better understand how different regions of the outflow tract contribute to fluid dynamics and intraocular pressure. The approach involves manipulating the model to observe real-time changes in fluid flow and tissue behavior, which could lead to insights into conditions like glaucoma. Patients may benefit from improved understanding and potential new treatments for eye pressure-related issues.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for glaucoma or those experiencing elevated intraocular pressure.
Not a fit: Patients with conditions unrelated to aqueous humor outflow or those who do not have elevated intraocular pressure may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better treatments for glaucoma and other conditions related to eye pressure.
How similar studies have performed: Previous research has shown promise in using 3D models for studying biological systems, suggesting that this approach could yield valuable insights.
Where this research is happening
Syracuse, United States
- Upstate Medical University — Syracuse, United States (Active)
Researchers
- Principal investigator: Herberg, Samuel — Upstate Medical University
- Study coordinator: Herberg, Samuel
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.