Connectome 2.0: A high-performance brain MRI resource for studying brain circuits
Official title: Connectome 2.0: A BRAIN Technology Integration and Dissemination Resource for Ultra-High Gradient Magnetic Resonance Imaging of Human Brain Circuits Across Scales
Funded at Massachusetts General Hospital · NIH-11377685 · Data updated 2026-11-12
A special MRI resource at Massachusetts General Hospital is being shared with researchers worldwide to help study brain circuits in living people.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | August 15, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2026 |
| Award (this year) | $1,302,808 |
| NIH project number | 5U24NS137077-03 |
| Project ID | NIH-11377685 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not applicable to a specific patient group in this grant; this is a resource dissemination effort for researchers who study brain disorders.
✕Less likely to help
This grant does not directly enroll patients or test therapies.
What this research studies
This grant funds dissemination of Connectome 2.0, a next‑generation 3T MRI scanner designed to map brain circuits across scales. It emphasizes ultra-high gradient strength and fast imaging to capture neural tissue microstructure with high fidelity. Researchers from around the world will be able to access and use advanced pulse sequences and validated measurements to study brain function and structure, including conditions like Alzheimer’s disease, dementia, and autism. The project includes calibration in phantoms and ex vivo tissue to ensure data quality across sites.
Why it matters
Potential benefit: Patients could benefit indirectly through faster progress in understanding brain diseases and development of better imaging tools.
How similar studies have gone: Previous Connectome projects demonstrated feasibility and broad use; this builds on that success with a more advanced scanner.
Where this research is happening
-
Massachusetts General Hospital
Boston, United States Active
Researchers
- Principal investigator: Huang, Susie Yi — Massachusetts General Hospital
- Study coordinator: Huang, Susie Yi
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.