Computational modeling of female hormone balance and drug responses
Official title: Computational Modeling of Female Hormone Homeostasis and Drug Responses
Funded at Henry Ford Health + Michigan State University Health Sciences · NIH-11562918 · Data updated 2026-11-12
A new computational model uses patient-like data to predict how metabolic drugs will work in women across their hormonal cycles and different reproductive stages.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Henry Ford Health + Michigan State University Health Sciences NIH-funded |
| Lab location | 1 site (East Lansing, United States) |
| Project start | September 14, 2026 |
| Project end | September 13, 2027 |
| Funding year | 2026 |
| Award (this year) | $4,587,853 |
| NIH project number | 1OT2OD042764-01 |
| Project ID | NIH-11562918 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with or at risk for metabolic diseases (e.g., diabetes, obesity) for whom female hormone dynamics may influence drug response.
✕Less likely to help
Patients whose treatment does not involve metabolic drugs or whose conditions are not influenced by hormonal fluctuations.
What this research studies
This project creates a multi-scale computer model that links hormone cycles with how body tissues respond to medications related to obesity and diabetes. It uses an equation-based framework to simulate hormone-tied drug effects and aims to predict efficacy and side effects in women. The goal is to improve drug safety and effectiveness for female patients by accounting for reproductive endocrinology in metabolic therapies.
Why it matters
Potential benefit: If successful, this work could lead to more accurate dosing and better outcomes for women taking metabolic medicines.
How similar studies have gone: Previous modeling work shows promise, but comprehensive female hormone-metabolism integration is an emerging field with potential for substantial impact.
Where this research is happening
-
Henry Ford Health + Michigan State University Health Sciences
East Lansing, United States Active
Researchers
- Principal investigator: Woodruff, Teresa K — Henry Ford Health + Michigan State University Health Sciences
- Study coordinator: Woodruff, Teresa K
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.