Computational analysis of transcriptome rearrangements in SARS-CoV-2
Funded at Rutgers the State Univ of Nj Camden · NIH-11400974 · Data updated 2026-11-12
A computer-based project from Rutgers-Camden will look at how the coronavirus may rearrange its RNA to create new proteins, which could inform future drugs and vaccines.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers the State Univ of Nj Camden NIH-funded |
| Lab location | 1 site (Camden, United States) |
| Project start | September 1, 2025 |
| Project end | August 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $157,000 |
| NIH project number | 5R16GM158776-02 |
| Project ID | NIH-11400974 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not applicable to direct patient participation; the work uses viral data and computational analyses.
✕Less likely to help
Patients who are not affected by COVID-19 or whose data are not used in this analysis would not benefit directly.
What this research studies
This project develops user-friendly computational tools to identify non-canonical RNA junctions in the coronavirus transcriptome, which may reveal new viral proteins and mechanisms. The team will create an open-source software pipeline so researchers can apply it to SARS-CoV-2 and other pathogens. By analyzing large datasets from the pandemic years, the work aims to strengthen pandemic preparedness and guide future therapeutic strategies.
Why it matters
Potential benefit: If successful, the tools could uncover new viral targets and help accelerate the development of treatments and vaccines.
How similar studies have gone: Previous studies have used RNA analysis to uncover viral biology, but identifying non-canonical junctions in coronaviruses is a novel, promising approach.
Where this research is happening
-
Rutgers the State Univ of Nj Camden
Camden, United States Active
Researchers
- Principal investigator: Grigoriev, Andrey — Rutgers the State Univ of Nj Camden
- Study coordinator: Grigoriev, Andrey
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.