Complete reproductive history and its link to maternal death and serious heart problems
Official title: Complete reproductive history and risk of maternal mortality and serious cardiovascular events
Funded at Vanderbilt University Medical Center · NIH-11454531 · Data updated 2026-11-12
A study using birth and health records to understand how a woman’s pregnancy history may relate to serious heart and maternal health outcomes later in life.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project start | September 1, 2026 |
| Project end | August 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $481,250 |
| NIH project number | 1R21HD120973-01A1 |
| Project ID | NIH-11454531 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are women with prior pregnancy complications or those who may have risk factors identified in birth and health records.
✕Less likely to help
Results may be less directly relevant for women without a history of adverse pregnancy outcomes.
What this research studies
This project will link birth certificates, death records, and hospital data to examine how adverse pregnancy outcomes throughout a woman’s reproductive years relate to severe maternal morbidity and cardiovascular events. It will combine large state registries to study patterns across many women and identify combinations of pregnancy complications that raise risk. The goal is to map long-term health risks so clinicians can better monitor and protect women with complex pregnancy histories.
Why it matters
Potential benefit: If successful, this work could improve long-term cardiovascular risk prediction for women and inform targeted monitoring after pregnancy complications.
How similar studies have gone: Prior research suggests links between some APOs and cardiovascular risk, but this project explores cumulative and combinatorial effects using comprehensive registries.
Where this research is happening
-
Vanderbilt University Medical Center
Nashville, United States Active
Researchers
- Principal investigator: Grijalva, Carlos G — Vanderbilt University Medical Center
- Study coordinator: Grijalva, Carlos G
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.