Comparing two methods for creating vascular access for kidney dialysis
Official title: Comparing surgical and endovascular arteriovenous fistula creation
Funded at University of California Los Angeles · NIH-10709628 · Data updated 2026-11-12
This study is looking at two ways to create a special connection in your blood vessels that helps people with kidney disease get dialysis, comparing traditional surgery with a newer method to see which one works better and is safer for you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | September 25, 2022 |
| Project end | August 31, 2026 |
| Funding year | 2023 |
| Award (this year) | $306,378 |
| NIH project number | 5R01DK132422-02 |
| Project ID | NIH-10709628 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with end-stage kidney disease who require hemodialysis and need vascular access.
✕Less likely to help
Patients who are not candidates for either surgical or endovascular arteriovenous fistula creation may not benefit from this research.
What this research studies
This research investigates the outcomes of two different techniques for creating arteriovenous fistulas (AVFs), which are essential for patients undergoing hemodialysis due to end-stage kidney disease. One technique is traditional surgery, while the other is a newer endovascular method. The study aims to gather data on the effectiveness and safety of these methods to help inform future treatment decisions for patients. By comparing the procedural outcomes, the research seeks to identify which method may provide better results for patients requiring vascular access.
Why it matters
Potential benefit: If successful, this research could lead to improved vascular access options for patients on hemodialysis, potentially enhancing their treatment outcomes and quality of life.
How similar studies have gone: While there have been small-scale studies on endovascular techniques, this research aims to provide the first comprehensive comparison of endoAVF and surgAVF outcomes, making it a novel approach.
Where this research is happening
-
University of California Los Angeles
Los Angeles, United States Active
Researchers
- Principal investigator: Woo, Karen — University of California Los Angeles
- Study coordinator: Woo, Karen
Related research
Other NIH-funded projects on the same topics.
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Cardiovascular changes after AV fistula creation and how autophagy affects it
A VA-led project looks at how blood vessel remodeling after AV fistula surgery may be helped by understanding and targeting autophagy.
-
Nanoparticle delivery to prevent AV fistula narrowing
A new nanoparticle-based approach aims to prevent AV fistula narrowing in people with kidney failure who rely on dialysis.
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Molecular control of arterial-to-vein remodeling in fistula maturation
This study explores how vein cells change to help arteriovenous fistulas mature, with the aim of improving outcomes for people needing hemodialysis.
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How the protein calprotectin affects healing of dialysis fistulas
Looking at whether a protein called calprotectin causes narrowing that keeps new dialysis fistulas from becoming usable for people with kidney failure.
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Improving AV fistula longevity by guiding vein remodeling
A research project is exploring how to help veins adapt better when used for hemodialysis access so patients have fewer costly procedures.
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Bioabsorbable wrap to improve AV fistula outcomes
A new bioabsorbable wrap is being studied to help AV fistula surgery heal better and stay open longer for people needing hemodialysis.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.