Bioabsorbable wrap to improve AV fistula outcomes
Official title: Characterization of the Long-Term Degradation of a Novel, Bioabsorbable Perivascular Wrap to Improve Outcomes in Arteriovenous Fistula Creation Surgery
Funded at Venostent, INC. · NIH-11358673 · Data updated 2026-11-12
A new bioabsorbable wrap is being studied to help AV fistula surgery heal better and stay open longer for people needing hemodialysis.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Venostent, INC. NIH-funded |
| Lab location | 1 site (Houston, UNITED STATES) |
| Project start | September 15, 2026 |
| Project end | May 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $404,385 |
| NIH project number | 1R33HL185606-01 |
| Project ID | NIH-11358673 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are adults with chronic kidney disease who require AV fistula creation and are eligible for participation in preclinical or translational testing.
✕Less likely to help
Not applicable to non-surgical patients or those not undergoing AV fistula creation.
What this research studies
This project tests a novel bioabsorbable perivascular wrap placed around vessels during AV fistula creation to support the vein as it adapts to arterial pressure. It uses an animal model to understand long-term degradation and its effect on vessel healing and patency. The goal is to reduce early failure and abandonment of AV fistulas, potentially improving dialysis access and survival for patients with kidney disease.
Why it matters
Potential benefit: If successful, the wrap could reduce AV fistula failures and improve dialysis access longevity for patients with CKD.
How similar studies have gone: Prior similar approaches in vascular devices have shown promise in supporting vessel healing, but long-term degradation and translation to human AV fistula outcomes remain to be demonstrated.
Where this research is happening
-
Venostent, INC.
Houston, United States Active
Researchers
- Principal investigator: Boire, Timothy Charles — Venostent, INC.
- Study coordinator: Boire, Timothy Charles
Related research
Other NIH-funded projects on the same topics.
-
Cardiovascular changes after AV fistula creation and how autophagy affects it
A VA-led project looks at how blood vessel remodeling after AV fistula surgery may be helped by understanding and targeting autophagy.
-
Nanoparticle delivery to prevent AV fistula narrowing
A new nanoparticle-based approach aims to prevent AV fistula narrowing in people with kidney failure who rely on dialysis.
-
Molecular control of arterial-to-vein remodeling in fistula maturation
This study explores how vein cells change to help arteriovenous fistulas mature, with the aim of improving outcomes for people needing hemodialysis.
-
How the protein calprotectin affects healing of dialysis fistulas
Looking at whether a protein called calprotectin causes narrowing that keeps new dialysis fistulas from becoming usable for people with kidney failure.
-
Improving AV fistula longevity by guiding vein remodeling
A research project is exploring how to help veins adapt better when used for hemodialysis access so patients have fewer costly procedures.
-
AI tool to screen AV fistula stenosis using stethoscope sounds in dialysis patients
A new AI tool uses sound recordings from a digital stethoscope to screen for narrowing in dialysis fistulas, helping clinicians catch problems earlier.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.