Colorectal Cancer: Targeting IGF2BP1 to overcome drug resistance
Official title: Colorectal Cancer Treatment and Drug Resistance; the Role of IGF2BP1
Funded at Jackson State University · NIH-11382118 · Data updated 2026-11-12
This grant explores whether blocking IGF2BP1 can make colorectal cancer cells more responsive to chemotherapy in patients with advanced disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Jackson State University NIH-funded |
| Lab location | 1 site (Jackson, United States) |
| Project start | August 1, 2025 |
| Project end | July 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $146,280 |
| NIH project number | 5R16GM153544-02 |
| Project ID | NIH-11382118 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with advanced colorectal cancer who have or may develop resistance to standard chemotherapy could ultimately benefit from this research.
✕Less likely to help
Early-stage patients or those whose tumors do not depend on IGF2BP1 pathways may see little direct benefit.
What this research studies
Colorectal cancer often stops responding to standard chemotherapy, and this project tests a new approach aimed at the IGF2BP1 protein, which is linked to cancer growth and drug resistance. Researchers will study how inhibiting IGF2BP1 affects cancer cells in lab settings and in animal models, with a goal of improving treatment effectiveness. The work builds on existing data showing that targeting IGF2BP1 may sensitize tumors to chemotherapy and seeks to translate those findings into potential new therapies for patients. Successful results could lead to more effective drugs that help shrink tumors and extend survival for people with resistant colorectal cancer.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that make chemotherapy work better for colorectal cancer patients.
How similar studies have gone: Preclinical data suggest IGF2BP1 inhibition can sensitize colorectal cancer cells to drugs, supporting potential translation to therapies.
Where this research is happening
-
Jackson State University
Jackson, United States Active
Researchers
- Principal investigator: Noubissi, Felicite K — Jackson State University
- Study coordinator: Noubissi, Felicite K
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.