Collaboratory advancing HIV cure research to eradicate persistent infection
Official title: Collaboratory of AIDS Researchers for Eradication (CARE)
Funded at Univ of North Carolina Chapel Hill · NIH-11515081 · Data updated 2026-11-12
A national team is pursuing new ways to cure HIV by waking up latent virus and helping the body clear infected cells, with the goal of eradicating persistent infection.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project start | August 18, 2026 |
| Project end | June 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $5,318,544 |
| NIH project number | 4UM1AI164567-06 |
| Project ID | NIH-11515081 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are people living with HIV who are on stable antiretroviral therapy and may participate in future latency-reversal or clearance studies.
✕Less likely to help
People not compatible with future clinical latency-reversal or clearance strategies may not directly benefit.
What this research studies
This project brings together researchers, clinicians, and industry partners to test new ideas that disrupt HIV latency and promote clearance of reservoir cells. It plans pre-clinical experiments, proof-of-concept studies, and strategies to prevent viral rebound after stopping therapy. The work emphasizes collaboration across institutions to translate promising concepts toward early clinical initiatives, aiming to move beyond treatment to potential cure. Participants would benefit indirectly through advances that could inform future therapies and trials.
Why it matters
Potential benefit: If successful, the research could inform new cure strategies that reduce or eliminate HIV reservoirs and prevent rebound after treatment interruption.
How similar studies have gone: Previous MDC efforts have shown progress in latency reversal and reservoir targeting, with ongoing translation to clinical testing.
Where this research is happening
-
Univ of North Carolina Chapel Hill
Chapel Hill, United States Active
Researchers
- Principal investigator: Margolis, David M. — Univ of North Carolina Chapel Hill
- Study coordinator: Margolis, David M.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.