Advancing gastric cancer care for Latinos through patient-derived tumor models
Official title: Advancing gastric cancer precision medicine in Latinos through patient-derived modeling
Funded at University of California at Davis · NIH-11603175 · Data updated 2026-11-12
Aimed at Latinos with gastric cancer, this project uses patient-derived tumor models to study how cancer biology and treatments work in real tumors.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $129,653 |
| NIH project number | 3U54CA283766-04S1 |
| Project ID | NIH-11603175 on NIH RePORTER |
Who could benefit from this research
✓Could help
Latino individuals diagnosed with gastric cancer, especially those whose tumors have PI3K/CDK pathway alterations.
✕Less likely to help
Patients without gastric cancer or without tumors carrying the targeted mutations may not benefit.
What this research studies
This grant focuses on gastric cancer disparities in Latinos and uses patient-derived xenograft models to study tumors with PI3K and CDK pathway alterations. Researchers will develop pre-clinical data and mechanistic insights to guide targeted therapies. The work is centered on translating findings to improve outcomes for Latino patients with gastric cancer who face higher disease burden.
Why it matters
Potential benefit: If successful, patients could receive more effective, personalized treatment options based on tumor biology.
How similar studies have gone: Previous work with patient-derived models in cancer has shown that personalized models can predict drug responses and guide therapy.
Where this research is happening
-
University of California at Davis
Davis, United States Active
Researchers
- Principal investigator: Carvajal Carmona, Luis Guillermo — University of California at Davis
- Study coordinator: Carvajal Carmona, Luis Guillermo
Related research
Other NIH-funded projects on the same topics.
-
Circulating metabolites as early warning signs for gastric cancer
Researchers will look at blood-based metabolites to find signs that predict gastric cancer risk in people, with a focus on those in large, multi-center cohorts.
-
Understanding why racial differences exist in stomach cancer in the US
This grant studies why some racial groups in the US have higher stomach cancer rates, focusing on how Helicobacter pylori infection and host responses contribute to these differences.
-
Understanding how gastric cancer starts and grows in the stomach
Researchers at Columbia are studying how two main types of stomach cancer begin and progress, using new mouse models and advanced single-cell and spatial analysis to map where cancer cells come from and how they change.
-
Gastric cancer prevention and screening modeled to guide US care
A nationwide modeling project uses AI and advanced simulations to help decide who should be tested and treated for stomach cancer prevention and screening in the United States.
-
Improved fibrin-targeted radiopharmaceutical for gastric cancer
A new radiopharmaceutical targets fibrin in gastric cancer to help treat advanced disease with potentially fewer side effects.
-
Drivers of early malignant change in diffuse gastric cancer
A research project aims to understand what triggers the transformation of stomach cells into cancer in people with diffuse gastric cancer, especially those with hereditary risk.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.