Chlamydia trachomatis and its effects on host cells
Official title: Chlamydia trachomatis manipulates (PI)CALM to carry on
Funded at University of Nebraska Medical Center · NIH-10950429 · Data updated 2026-11-12
This study is looking at how the Chlamydia bacteria trick our body's cells to hide and cause infections, especially in women, with the goal of finding ways to prevent these infections and their serious health effects.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Medical Center NIH-funded |
| Lab location | 1 site (Omaha, United States) |
| Project start | September 4, 2024 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $207,225 |
| NIH project number | 1R21AI185536-01 |
| Project ID | NIH-10950429 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are women aged 15 to 19 who are at risk of Chlamydia trachomatis infections.
✕Less likely to help
Patients who are not at risk for Chlamydia infections or who are already experiencing severe complications may not benefit from this research.
What this research studies
This research investigates how the bacterium Chlamydia trachomatis manipulates host cell processes to establish and maintain infections, particularly in women. It focuses on understanding the mechanisms that allow the bacteria to remain undetected by the immune system, which can lead to serious health issues like pelvic inflammatory disease and infertility. By studying the lifecycle of the bacteria within host cells, the research aims to identify potential strategies for preventing transmission and limiting infections. The approach includes examining the interactions between the bacteria and host cell components during infection.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing Chlamydia infections and their associated complications in women.
How similar studies have gone: Previous research has shown success in understanding bacterial infections and their interactions with host cells, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Nebraska Medical Center
Omaha, United States Active
Researchers
- Principal investigator: Rucks, Elizabeth Ann — University of Nebraska Medical Center
- Study coordinator: Rucks, Elizabeth Ann
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.