NIH-funded research NIH-funded research

CBT for chronic pain in veterans with serious mental illness

Official title: Exploring the Efficacy of Cognitive Behavorial Therapy for Chronic Pain in Veterans with Serious Mental Illness

Funded at Baltimore VA Medical Center · NIH-11111742 · Data updated 2026-11-12

A government-funded program tests whether a talk-based therapy called CBT-CP helps veterans who have both chronic pain and serious mental illness feel better and function more normally.

More Chronic Pain research and trials

Quick facts

Grant typeNIH-funded research
Study typeNIH-funded research
Funding institutionBaltimore VA Medical Center
NIH-funded
Lab location1 site (Baltimore, United States)
Project startOctober 1, 2025
Project endSeptember 30, 2029
Funding year2027
NIH project number1I01RX005049-01A2
Project IDNIH-11111742 on NIH RePORTER

Who could benefit from this research

Could help

Ideal participants are veterans with serious mental illness who experience chronic low back pain and are eligible for CBT-CP.

Less likely to help

Patients without chronic musculoskeletal pain or without SMI may not directly benefit from this specific trial.

What this research studies

This project will test a non-drug therapy called Cognitive Behavioral Therapy for Chronic Pain specifically in veterans who have serious mental illness. Researchers plan a randomized trial to see if CBT-CP reduces pain interference and improves daily functioning in this group. If successful, the study aims to support wider adoption of CBT-CP across the VA system for patients who face both chronic pain and mental health challenges. The effort addresses a real-world clinical need by focusing on nonpharmacological pain management within a vulnerable population.

Why it matters

Potential benefit: If effective, CBT-CP could improve pain control and daily functioning for veterans with SMI, potentially reducing hospitalizations and improving quality of life.

How similar studies have gone: Similar nonpharmacological pain therapies have helped other populations, but this exact combination in veterans with SMI is novel and exploratory.

Where this research is happening

  • Baltimore VA Medical Center
    Baltimore, United States
    Active

Researchers

  • Principal investigator: Travaglini, Letitia — Baltimore VA Medical Center
  • Study coordinator: Travaglini, Letitia

Related research

Other NIH-funded projects on the same topics.

  • Motor cortex tricks to ease chronic pain

    A study in rodents and people tests whether non-invasive brain stimulation of the motor cortex can reduce chronic pain and how best to target it.

    NIH research Weill Medical Coll of Cornell Univ · New York, United States · NIH-11621209

  • Human pain center study to map normal and migraine-trigeminal neurons

    A large NIH-funded project will map and study the human trigeminal neurons involved in migraines to understand what changes in these cells during headache conditions.

    NIH research University of Pennsylvania · Philadelphia, United States · NIH-11615140

  • Understanding human pain neurons to improve migraine care

    Researchers are studying human pain-sensing neurons to uncover what makes migraine start and persist, with the goal of better treatments for people who experience migraines.

    NIH research University of Pennsylvania · Philadelphia, United States · NIH-11615139

  • Whole Person Pain Algorithm to personalize chronic pain care

    A new, evidence-based model helps explain why chronic low back pain affects people differently and could guide personalized diagnosis and treatment.

    NIH research University of Florida · Gainesville, United States · NIH-11609318

  • Understanding how to use pharmacogenomic testing to guide chronic pain care

    This grant looks at how doctors who treat long‑term pain decide when and how to use genetic testing to tailor pain medicines for safer and more effective care.

    NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11602241

  • Mindfulness and Self-Hypnosis for Pain in Older Adults

    This grant tests non-drug ways like mindfulness and self-hypnosis to help people over 60 manage chronic pain.

    NIH research University of Washington · Seattle, United States · NIH-11599794

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.