Causes of sex differences in children born from pregnancies affected by preeclampsia
Official title: Causes of Sex Differences in male and female offspring born from inflammation mediated hypertensive pregnancy
Funded at University of Mississippi Med Ctr · NIH-11397742 · Data updated 2026-11-12
This grant aims to understand why male and female offspring differ in health outcomes when the mother has preeclampsia, and to explore potential treatments to improve long-term cardiovascular and brain health for these children.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Mississippi Med Ctr NIH-funded |
| Lab location | 1 site (Jackson, United States) |
| Project start | August 15, 2025 |
| Project end | July 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $1,443,428 |
| NIH project number | 5U54HL170290-02 |
| Project ID | NIH-11397742 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates include pregnant people at risk for or affected by preeclampsia and researchers seeking therapies applicable to improving outcomes for offspring.
✕Less likely to help
Direct patient benefit would be limited to future translation; current work uses animal models to uncover mechanisms and targets.
What this research studies
Researchers will study how placental blood flow problems in preeclampsia affect a mother’s blood pressure, brain and kidney function, and how these changes may differently impact sons and daughters. Using animal models that mimic human preeclampsia, the team will probe mechanisms and test potential therapies to prevent lasting health problems in offspring. The work builds on established models and focuses on identifying targets that could lead to treatments to protect mothers and children from hypertension and related complications after birth.
Why it matters
Potential benefit: If successful, the research could reveal new targets for therapies that reduce maternal and offspring risk of hypertension and organ dysfunction after preeclampsia.
How similar studies have gone: Previous animal-model studies have linked placental ischemia to maternal cardiovascular dysfunction and offspring programming, supporting further exploration in this area.
Where this research is happening
-
University of Mississippi Med Ctr
Jackson, United States Active
Researchers
- Principal investigator: Lamarca, Babbette — University of Mississippi Med Ctr
- Study coordinator: Lamarca, Babbette
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.