NIH-funded research R01 grant

Cannabis legalization and use of cannabis, nicotine, and alcohol among youth with mental illness

Official title: The Impact of Cannabis Legalization on Cannabis, Nicotine and Alcohol Use among Youth with Mental Illness

Funded at Cambridge Health Alliance · NIH-11276456 · Data updated 2026-11-12

This grant explores how legalizing cannabis affects how young people with mental illness use cannabis, nicotine, and alcohol and what that means for their health.

More Alcohol Use research and trials

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionCambridge Health Alliance
NIH-funded
Lab location1 site (Cambridge, United States)
Project startJune 15, 2026
Project endMarch 31, 2031
Funding year2026
Award (this year)$776,604
NIH project number1R01DA064695-01
Project IDNIH-11276456 on NIH RePORTER

Who could benefit from this research

Could help

Adolescents and young adults (approximately ages 12-25) with a diagnosed mental illness who may be affected by cannabis legalization.

Less likely to help

Youth without mental illness or those not using cannabis, nicotine, or alcohol may see limited direct benefit.

What this research studies

Young people aged 12 to 25 with mental illness are being studied to understand how changes in cannabis laws influence their use of cannabis, nicotine, and alcohol. The project combines large-scale data analysis with in-depth interviews to capture both numbers and real-life experiences. Researchers will look at how often these substances are used, how risky people perceive them to be, and how likely disorders related to use are to occur. Findings could help tailor public health messages and services for vulnerable youth during policy transitions.

Why it matters

Potential benefit: If successful, the study could inform better prevention and treatment strategies for youths with mental illness who are at risk of substance use, potentially reducing harm.

How similar studies have gone: Previous work suggests policy changes can shift usage patterns, but this study combines quantitative and qualitative methods in a specific high-risk group for novel insights.

Where this research is happening

  • Cambridge Health Alliance
    Cambridge, United States
    Active

Researchers

  • Principal investigator: Cook, Benjamin Le — Cambridge Health Alliance
  • Study coordinator: Cook, Benjamin Le

Related research

Other NIH-funded projects on the same topics.

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  • Predictors and outcomes of using cannabis and alcohol at the same time in daily life

    A daily-life study with young adults to understand what leads to and happens after using cannabis and alcohol together, to pave the way for timely help in real-world settings.

    NIH research Arizona State University-Tempe Campus · Scottsdale, United States · NIH-11367613

  • Helping adolescents reduce alcohol and cannabis use through cognitive training

    This study is trying out a new computer program to help teens who want to cut back on drinking alcohol and using cannabis by changing how they react to pictures of these substances, with the hope that it will help them use less.

    NIH research Medical University of South Carolina · Charleston, United States · NIH-11053604

  • Exploring how sleep affects withdrawal from cannabis and alcohol use disorders

    This study is looking at how sleep problems might affect feelings and brain activity in people who are trying to quit using both cannabis and alcohol, and it will involve tracking 40 adults over a month to better understand these connections and help improve treatment options.

    NIH research Palo Alto Veterans Instit for Research · Palo Alto, United States · NIH-10698188

  • Biomarkers to detect recent heavy drinking in veterans

    A doctor-scientist team is testing blood biomarkers to better identify recent excessive alcohol use in veterans so clinicians can screen, counsel, and care for those at risk.

    NIH research Rlr VA Medical Center · Indianapolis, United States · NIH-11685217

  • Understanding how heavy drinking and anxiety relate in emerging adults

    This grant studies how heavy alcohol use and anxiety symptoms interact in young adults (ages 18–34) and what biological stress markers might reveal about that relationship.

    NIH research Brown University · Providence, United States · NIH-11627893

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.