Can risk-reducing meds help prevent breast cancer in survivors of childhood/adolescent cancer
Official title: Can risk-reducing medications improve breast cancer prevention in childhood and adolescent cancer survivors? Comparative modeling to inform care
Funded at Boston Children's Hospital · NIH-11413586 · Data updated 2026-11-12
A modeling study to see if medicines that lower breast cancer risk could help survivors of childhood and teenage cancer, especially those who had chest radiation.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 1, 2022 |
| Project end | August 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $602,181 |
| NIH project number | 5R01CA261874-05 |
| Project ID | NIH-11413586 on NIH RePORTER |
Who could benefit from this research
✓Could help
Female survivors of childhood or adolescent cancer who received chest radiation or high-dose anthracycline chemotherapy and are at high risk for breast cancer.
✕Less likely to help
Survivors without significant exposure to radiation or chemotherapy or those with contraindications to preventive medications may see limited benefit.
What this research studies
This project uses computer models and long-term data to estimate how well risk-reducing drugs work for women who survived childhood or adolescent cancer and were exposed to chest radiation or high-dose anthracyclines. It aims to identify which survivors might benefit most and how to overcome barriers like cost and access to care. The goal is to inform doctors and families about prevention options that could reduce the chance of developing ER-positive breast cancer later in life. Because it relies on existing data and simulations, it seeks to guide future clinical decisions without requiring large new trials right away.
Why it matters
Potential benefit: If successful, it could support personalized prevention plans that lower breast cancer risk for young cancer survivors.
How similar studies have gone: Previous studies and guidelines support risk-reducing strategies in high-risk women, but this exact survivor population has limited prospective trial data.
Where this research is happening
-
Boston Children's Hospital
Boston, United States Active
Researchers
- Principal investigator: Yeh, Jennifer M. — Boston Children's Hospital
- Study coordinator: Yeh, Jennifer M.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.