Calcium-Dependent Self-Regulation of Vasopressin Neurons in Heart Failure (Rodent Model)
Official title: Calcium-dependent autoregulation of vasopressin neurons in a rodent model of heart failure.
Funded at Texas A&m University Health Science Ctr · NIH-11365216 · Data updated 2026-11-12
Researchers will study how brain cells that release vasopressin control their own activity and how this changes in a rodent model of heart failure.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Texas A&m University Health Science Ctr NIH-funded |
| Lab location | 1 site (College Station, United States) |
| Project start | July 1, 2025 |
| Project end | May 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $249,000 |
| NIH project number | 5R00HL168434-04 |
| Project ID | NIH-11365216 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates would be researchers who are pursuing independent academic careers in neuroendocrinology or cardiovascular physiology with a focus on translational relevance to heart failure.
✕Less likely to help
This project is conducted in rodent models, so direct patient benefits would emerge only if findings translate to human studies.
What this research studies
In this study, scientists at Texas A&M will look at how vasopressin neurons regulate their firing and local release of vasopressin, especially when heart failure is present. They will explore the role of calcium signaling and afterhyperpolarization in shaping neuron activity and how these processes interact with autocrine/paracrine feedback. The project aims to build the investigator’s independent research trajectory while addressing a key aspect of heart failure related to nervous and hormonal regulation. The work could reveal targets to modulate vasopressin signaling in patients with heart failure.
Why it matters
Potential benefit: Understanding these mechanisms could identify new ways to stabilize nervous system and hormonal regulation in heart failure patients.
How similar studies have gone: Preliminary data suggest shared signaling pathways between afterhyperpolarization and vasopressin somatodendritic release, indicating potential for meaningful advances.
Where this research is happening
-
Texas A&m University Health Science Ctr
College Station, United States Active
Researchers
- Principal investigator: Kirchner, Matthew — Texas A&m University Health Science Ctr
- Study coordinator: Kirchner, Matthew
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.