NIH-funded research U01 cooperative agreement

Building a big study of colorectal cancer risk in Alaska Native people

Official title: Building a Cancer Epidemiology Cohort to Investigate Factors Associated with Higher Risk of Colorectal Cancer among Alaska Native People

Funded at Alaska Native Tribal Health Consortium · NIH-11395374 · Data updated 2026-11-12

A large research project will follow Alaska Native adults to learn why colorectal cancer occurs more often in this population and how to prevent it.

More Colorectal Cancer research and trials

Quick facts

Grant typeU01 cooperative agreement
Study typeNIH-funded research
Funding institutionAlaska Native Tribal Health Consortium
NIH-funded
Lab location1 site (Anchorage, United States)
Project startAugust 1, 2024
Project endJuly 31, 2029
Funding year2026
Award (this year)$445,427
NIH project number5U01CA290673-03
Project IDNIH-11395374 on NIH RePORTER

Who could benefit from this research

Could help

Adults 21 years or older who are Alaska Native and undergoing colonoscopy will be invited to participate.

Less likely to help

People who are not Alaska Native or who are not undergoing colonoscopy may not directly benefit from the study.

What this research studies

This project creates the first community-engaged cohort to study colorectal cancer risk among Alaska Native people. It will enroll 1,000 adults who are scheduled for colonoscopy in Anchorage and nearby communities to collect information and samples over time. The researchers aim to identify new risk factors that could lead to better primary prevention and more accurate risk prediction. The study builds on a successful pilot and partners with Alaska Native Tribal Health Consortium and Fred Hutchinson Cancer Center. Participants can expect careful follow-up and access to potential future prevention strategies tied to the findings.

Why it matters

Potential benefit: If successful, the study could lead to new ways to prevent colorectal cancer and tailor screening for Alaska Native people.

How similar studies have gone: This is the first large cohort study focusing on CRC risk in Alaska Native people, building on a prior pilot.

Where this research is happening

  • Alaska Native Tribal Health Consortium
    Anchorage, United States
    Active

Researchers

  • Principal investigator: Redwood, Diana — Alaska Native Tribal Health Consortium
  • Study coordinator: Redwood, Diana

Related research

Other NIH-funded projects on the same topics.

  • Improving colorectal cancer screening and follow-up care.

    This study is working to help more people get screened for colorectal cancer and receive the follow-up care they need, especially those who haven't been screened much before, so that everyone can have better access to important health checks and improve their overall health.

    NIH research Research Triangle Institute · Research Triangle Park, United States · NIH-9627071

  • Colorectal cancer prognosis through a broad, collaborative study

    A large, multi-center study follows people newly diagnosed with colorectal cancer to find biomarkers and patterns that predict outcomes and guide future care.

    NIH research Utah State Higher Education System--University of Utah · Salt Lake City, United States · NIH-11590756

  • Ceramides and how they affect metabolism and colorectal cancer in adults

    A study in adults with obesity-related health issues will explore how a fat-related molecule called ceramide influences metabolic problems and colorectal cancer risk.

    NIH research Utah State Higher Education System--University of Utah · Salt Lake City, United States · NIH-11535283

  • Automated point-of-care DNA methylation test for colorectal cancer in LMICs

    A fast, affordable blood test using DNA markers to help identify people at higher risk of colorectal cancer in low- and middle-income countries.

    NIH research Johns Hopkins University · Baltimore, United States · NIH-11531863

  • Rewiring Colorectal Cancer to Harness Therapeutic Hyperactivation

    A Yale team is exploring brain-storming new ways to treat colorectal cancer by safely boosting certain cancer signaling pathways to kill cancer cells and by reshaping cancer cell states to improve responses to existing therapies.

    NIH research Yale University · New Haven, United States · NIH-11505210

  • Comparative modeling to guide colorectal cancer screening and care

    A researcher team will use computer models to study how access to care, risk, and new screening options affect colorectal cancer outcomes and costs for adults in the US.

    NIH research Utah State Higher Education System--University of Utah · Salt Lake City, United States · NIH-11495363

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.