Brain lipoprotein structure and APOE effects on amyloid in Alzheimer's disease
Official title: The impact of brain lipoprotein structure and composition on amyloid beta metabolism and Alzheimer's disease
Funded at Battelle Pacific Northwest Laboratories · NIH-11352560 · Data updated 2026-11-12
This grant would study how brain lipoproteins and APOE variants affect Alzheimer's disease processes to better understand disease risk and progression in older adults.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Battelle Pacific Northwest Laboratories NIH-funded |
| Lab location | 1 site (Richland, United States) |
| Project start | July 15, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2026 |
| Award (this year) | $676,324 |
| NIH project number | 5R01NS125591-03 |
| Project ID | NIH-11352560 on NIH RePORTER |
Who could benefit from this research
✓Could help
Older adults, particularly those at risk for or diagnosed with Alzheimer’s disease, may be eligible if they contribute CSF samples or participate in related analyses.
✕Less likely to help
Individuals without AD risk or with non-AD neurodegenerative conditions may not benefit from this specific research focus.
What this research studies
Older adults with or at risk for Alzheimer's disease could benefit from new insights into how brain fats and APOE variants influence amyloid buildup. The project uses a new fluorescent lipoprotein profiling method and advanced protein/lipid analysis to map the different brain lipoprotein particles in cerebrospinal fluid and see how APOE forms change their behavior. By linking specific lipoprotein structures to amyloid pathology, the work may identify new biomarkers or targets for therapy. The research combines cutting-edge techniques with patient-relevant biology to illuminate pathways behind memory loss and cognitive decline in AD.
Why it matters
Potential benefit: Potential to clarify mechanisms behind AD and identify new biomarkers or targets that could guide future therapies.
How similar studies have gone: Prior work using lipoprotein profiling and APOE biology has provided insights, but this exact CSF BLp profiling approach is novel and promising.
Where this research is happening
-
Battelle Pacific Northwest Laboratories
Richland, United States Active
Researchers
- Principal investigator: Melchior, John — Battelle Pacific Northwest Laboratories
- Study coordinator: Melchior, John
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.