Blood test to find dangerous brain aneurysms
Development of a Molecular Diagnostic to Identify Dangerous Intracranial Aneurysms
This project is creating a blood test to help doctors tell which people with brain aneurysms are more likely to have a dangerous rupture.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Neurovascular Diagnostics, INC. NIH-funded |
| Lab location | 1 site (Buffalo, United States) |
| Project ID | NIH-11163352 on NIH RePORTER |
What this research studies
If you have an unruptured brain aneurysm, this project is developing a blood test that looks for molecular signals linked to dangerous aneurysms. You may be asked to give a blood sample and share clinical information while researchers compare samples from people with stable aneurysms and those that proved high-risk. The team will use laboratory biomarker assays and computer algorithms to spot patterns that predict rupture risk without invasive angiography. The aim is a simpler, lower-risk test doctors can use alongside scans to guide treatment versus monitoring decisions.
Who could benefit from this research
Good fit: Adults with an unruptured intracranial aneurysm found on imaging who are weighing whether to monitor or treat their aneurysm.
Not a fit: People without aneurysms, those with a ruptured aneurysm needing emergency care, or patients unable to access participating centers may not benefit from this project.
Why it matters
Potential benefit: If successful, this could help avoid unnecessary procedures for low-risk aneurysms and speed treatment for those at high risk.
How similar studies have performed: Imaging-based risk scores exist, but blood-based tests to predict aneurysm rupture are mostly experimental and represent a relatively new approach.
Where this research is happening
Buffalo, United States
- Neurovascular Diagnostics, INC. — Buffalo, United States (Active)
Researchers
- Principal investigator: Poppenberg, Kerry — Neurovascular Diagnostics, INC.
- Study coordinator: Poppenberg, Kerry
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.