Identifying dangerous brain aneurysms using blood tests
Official title: Development of a Molecular Diagnostic to Identify Dangerous Intracranial Aneurysms
Funded at Neurovascular Diagnostics, INC. · NIH-10912433 · Data updated 2026-11-12
This study is working on a new blood test to help doctors find dangerous brain aneurysms that might burst, making it easier and safer to decide which ones need urgent treatment and which can be watched over time.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Neurovascular Diagnostics, INC. NIH-funded |
| Lab location | 1 site (Buffalo, United States) |
| Project start | September 30, 2019 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $1,286,865 |
| NIH project number | 5R44NS115314-03 |
| Project ID | NIH-10912433 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with unruptured intracranial aneurysms who are at risk of rupture.
✕Less likely to help
Patients with ruptured aneurysms or those without any diagnosed aneurysms may not benefit from this research.
What this research studies
This research focuses on developing a blood-based diagnostic tool to identify dangerous intracranial aneurysms (IAs) that have a high risk of rupture. Currently, clinicians rely on invasive imaging techniques to assess the risk of IAs, which can be costly and carry significant risks. By analyzing biological markers in blood samples, this study aims to provide a safer and more accurate method for determining which aneurysms require immediate treatment and which can be monitored over time. This approach could lead to better patient management and outcomes.
Why it matters
Potential benefit: If successful, this research could significantly improve the ability to identify high-risk aneurysms, potentially reducing mortality and disability rates associated with aneurysm ruptures.
How similar studies have gone: While there have been advancements in imaging techniques for aneurysm assessment, the development of a blood-based diagnostic tool for this purpose is a novel approach that has not been widely tested.
Where this research is happening
-
Neurovascular Diagnostics, INC.
Buffalo, United States Active
Researchers
- Principal investigator: Poppenberg, Kerry — Neurovascular Diagnostics, INC.
- Study coordinator: Poppenberg, Kerry
Related research
Other NIH-funded projects on the same topics.
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Blood test to detect intracranial aneurysms and estimate risk in families
A new blood test called AneuScreen+ aims to identify people at risk for brain aneurysms and predict rupture risk using a simple blood sample.
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Blood test to find dangerous brain aneurysms
This project is creating a blood test to help doctors tell which people with brain aneurysms are more likely to have a dangerous rupture.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.