Bioinformatics platform to map HIV vaccine B-cell responses
Official title: Mapping the B-Cell Repertoire Induced by HIV Vaccination: A Bioinformatics Platform for Integrated Analysis of B-Cell Receptor Sequences and Antibody Functions
Funded at Fred Hutchinson Cancer Center · NIH-11468160 · Data updated 2026-11-12
A national HIV vaccine research center is building a beginner-friendly data platform to study how B cells respond to HIV vaccines in people, with the goal of improving vaccines.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Fred Hutchinson Cancer Center NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | September 17, 2026 |
| Project end | August 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $879,407 |
| NIH project number | 1R24AI203347-01 |
| Project ID | NIH-11468160 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals enrolled in HIV vaccine trials and later recipients of bnAb-inducing immunogens may benefit from improved vaccine strategies.
✕Less likely to help
The platform itself does not deliver a treatment; participants not involved in vaccine trials may not directly benefit.
What this research studies
This grant funds a bioinformatics workflow that harmonizes and analyzes B-cell receptor sequences and antibody data from HIV vaccine trials. It focuses on making specialized analyses accessible to vaccine researchers by standardizing annotations, curation, and integration with clinical data. The work will curate data from DiscoMed trials and link it with other immunology information to reveal how B cells mature toward broadly neutralizing antibodies. The project leverages existing DataSpace resources to create a reusable platform for future studies. The aim is to lower barriers so more researchers can gain insights from complex B-cell data and advance HIV vaccine development.
Why it matters
Potential benefit: If successful, patients could benefit from faster development of effective HIV vaccines and better understanding of immune responses to vaccination.
How similar studies have gone: Previous work shows that harmonized BCR analysis can reveal important patterns in vaccine-induced antibody responses, though data sharing remains a challenge.
Where this research is happening
-
Fred Hutchinson Cancer Center
Seattle, United States Active
Researchers
- Principal investigator: Hyrien, Ollivier — Fred Hutchinson Cancer Center
- Study coordinator: Hyrien, Ollivier
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.