B-cell problems in chronic inflammatory demyelinating polyneuropathy (CIDP)
In-depth characterization of B-cell dysfunction in chronic inflammatory demyelinating polyneuropathy
Researchers are looking at how B cells and the antibodies they make may damage nerves in people with CIDP to help guide better treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11308721 on NIH RePORTER |
What this research studies
If you join, researchers may collect blood and, in some cases, nerve tissue to look for the types and targets of antibodies in people with CIDP. They will compare patients who have known nodal/paranodal autoantibodies to those who do not and measure B-cell features and antibody effects. Lab and animal tests may be used to see whether patient antibodies can injure nerves or slow nerve signals. The goal is to find markers that predict who might respond to B-cell–targeting therapies.
Who could benefit from this research
Good fit: Ideal candidates are adults diagnosed with CIDP who are willing to provide blood samples (and possibly nerve biopsy material or clinical data) and share treatment history.
Not a fit: People without CIDP or with neuropathies that are not autoimmune in nature are unlikely to benefit from this research.
Why it matters
Potential benefit: This work could help identify specific antibody-driven forms of CIDP and point to treatments, like B-cell–targeting therapies, that are more likely to work for particular patients.
How similar studies have performed: Prior work has identified autoantibodies against nodal/paranodal proteins and shown that some patients with those antibodies do better with B-cell depletion, but many CIDP patients still lack a known antibody and need more answers.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Roy, Bhaskar — Yale University
- Study coordinator: Roy, Bhaskar
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.