Understanding B-cell dysfunction in chronic inflammatory demyelinating polyneuropathy
Official title: In-depth characterization of B-cell dysfunction in chronic inflammatory demyelinating polyneuropathy
Funded at Yale University · NIH-11063185 · Data updated 2026-11-12
This study is looking into how certain immune cells called B-cells might be causing problems in people with chronic inflammatory demyelinating polyneuropathy (CIDP), with the goal of finding better treatments for this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $377,245 |
| NIH project number | 5R01NS132860-02 |
| Project ID | NIH-11063185 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with chronic inflammatory demyelinating polyneuropathy, particularly those who have not responded well to existing treatments.
✕Less likely to help
Patients with CIDP who have already achieved stable disease control without therapy may not benefit from this research.
What this research studies
This research investigates the role of B-cells in chronic inflammatory demyelinating polyneuropathy (CIDP), a rare autoimmune disease affecting the peripheral nervous system. It aims to identify the mechanisms behind B-cell dysfunction and how it contributes to the disease's progression. By analyzing patient sera and conducting animal model experiments, the research seeks to uncover the presence of pathogenic autoantibodies and their effects on nerve function. The findings could lead to improved treatment strategies for patients suffering from CIDP.
Why it matters
Potential benefit: If successful, this research could lead to more effective therapies for CIDP, potentially improving patient outcomes and quality of life.
How similar studies have gone: Previous research has shown promising results in understanding autoimmune mechanisms in similar conditions, suggesting potential for success in this area.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Roy, Bhaskar — Yale University
- Study coordinator: Roy, Bhaskar
Related research
Other NIH-funded projects on the same topics.
-
B-cell problems in chronic inflammatory demyelinating polyneuropathy (CIDP)
Researchers are looking at how B cells and the antibodies they make may damage nerves in people with CIDP to help guide better treatments.
-
Small skin sample to help detect and track CIDP
This project tests whether a tiny skin biopsy can help doctors find and follow CIDP in people who have or may have the condition.
-
Aging, T cells, and CIDP: how senescence may drive nerveautoimmunity
This grant looks at why CIDP, a chronic autoimmune nerve disease, happens more in older people by studying aging-like changes in immune cells and how they might push nerve cells to become dysfunctional.
-
KITE-363 treatment for relapsed or refractory autoimmune neurologic diseases
This study will test whether KITE-363 is safe and can help people with relapsed or treatment-resistant autoimmune neurologic diseases such as MS, CIDP, and myasthenia gravis.
-
Immunoadsorption treatment for chronic inflammatory demyelinating polyneuropathy
This observational study will try immunoadsorption as a next-step treatment for adults with CIDP who do not respond well to IVIg or methylprednisolone.
-
Empasiprubart for adults with CIDP
This study will test whether IV empasiprubart helps improve symptoms and is safe for adults with CIDP, with an initial 24-week randomized comparison to placebo followed by two years of empasiprubart for all participants.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.