Understanding B-cell dysfunction in chronic inflammatory demyelinating polyneuropathy
In-depth characterization of B-cell dysfunction in chronic inflammatory demyelinating polyneuropathy
['FUNDING_R01'] · YALE UNIVERSITY · NIH-11063185
This study is looking into how certain immune cells called B-cells might be causing problems in people with chronic inflammatory demyelinating polyneuropathy (CIDP), with the goal of finding better treatments for this condition.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-11063185 on ClinicalTrials.gov |
What this research studies
This research investigates the role of B-cells in chronic inflammatory demyelinating polyneuropathy (CIDP), a rare autoimmune disease affecting the peripheral nervous system. It aims to identify the mechanisms behind B-cell dysfunction and how it contributes to the disease's progression. By analyzing patient sera and conducting animal model experiments, the research seeks to uncover the presence of pathogenic autoantibodies and their effects on nerve function. The findings could lead to improved treatment strategies for patients suffering from CIDP.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with chronic inflammatory demyelinating polyneuropathy, particularly those who have not responded well to existing treatments.
Not a fit: Patients with CIDP who have already achieved stable disease control without therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective therapies for CIDP, potentially improving patient outcomes and quality of life.
How similar studies have performed: Previous research has shown promising results in understanding autoimmune mechanisms in similar conditions, suggesting potential for success in this area.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ROY, BHASKAR — YALE UNIVERSITY
- Study coordinator: ROY, BHASKAR
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.