Antipsychotic use during pregnancy and infant development
Official title: Developmental effects of antenatal exposure to antipsychotics
Funded at Icahn School of Medicine at Mount Sinai · NIH-11530214 · Data updated 2026-11-12
This project follows pregnant women with severe mental illness to see how taking antipsychotics during pregnancy affects maternal health, baby health at birth, and child development in the first 6 months.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | June 1, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $180,187 |
| NIH project number | 3R01HD111117-04S1 |
| Project ID | NIH-11530214 on NIH RePORTER |
Who could benefit from this research
✓Could help
Pregnant women with severe mental illness who are considering or receiving antipsychotic treatment.
✕Less likely to help
Pregnant women with severe mental illness not using antipsychotics and those without the condition may not experience direct benefits from this study.
What this research studies
If you are pregnant and have a serious mental illness, this study will observe your psychiatric course and look at how medications, including antipsychotics, influence outcomes for you and your baby. Researchers will compare those who take antipsychotics with those who take other medications or no medication, using careful matching to reduce confounding. They will collect detailed information about home environment, relationships, and health to understand factors that could impact outcomes and will analyze infant development at 6 months. The goal is to understand whether antipsychotics are effective for pregnant women with severe illness and whether they have any measurable effects on the newborn and early development.
Why it matters
Potential benefit: If successful, the study could clarify safety and effectiveness of antipsychotics in pregnancy, guiding safer treatment decisions for mothers and healthier development for babies.
How similar studies have gone: This approach builds on observational methods used in perinatal psychiatry and has shown value in understanding medication safety and outcomes.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Robakis, Thalia K — Icahn School of Medicine at Mount Sinai
- Study coordinator: Robakis, Thalia K
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.