Analyzing how individual cells behave and develop in tissues
Official title: In vivio single-cell analysis of dynamic cell behaviors
Funded at Sloan-Kettering Inst Can Research · NIH-11041051 · Data updated 2026-11-12
This study is looking at how individual cells move and change over time in tissues using special imaging techniques, which could help us better understand how our bodies develop and how diseases work.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | March 1, 2024 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $398,937 |
| NIH project number | 5R01GM152927-02 |
| Project ID | NIH-11041051 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to tissue development or abnormalities, such as birth defects.
✕Less likely to help
Patients with stable, non-progressive conditions or those not related to tissue development may not benefit from this research.
What this research studies
This research focuses on using advanced imaging techniques to observe and track the behavior of individual cells within tissues over time. By employing fluorescence 3D time-lapse imaging, researchers can monitor cell movements and lineage differentiation in real-time, providing insights into how tissues form and develop. The study aims to develop deep learning tools for accurate cell tracking and to integrate various imaging modalities to enhance our understanding of cell dynamics. This innovative approach could lead to breakthroughs in understanding complex biological processes and diseases.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of tissue development and potentially inform new treatments for developmental disorders and diseases.
How similar studies have gone: Previous research has shown success in using imaging and deep learning techniques to analyze cell behavior, indicating that this approach has potential for significant advancements.
Where this research is happening
-
Sloan-Kettering Inst Can Research
New York, United States Active
Researchers
- Principal investigator: Bao, Zhirong — Sloan-Kettering Inst Can Research
- Study coordinator: Bao, Zhirong
Related research
Other NIH-funded projects on the same topics.
-
Understand how skeletal muscle nuclei specialize and arrange themselves for proper muscle function
A study to uncover how the hundreds of nuclei in skeletal muscle fibers acquire different roles and positions to keep muscles strong and healthy.
-
Genomic profiling and outcomes of cancers in World Trade Center-exposed survivors and responders
This project looks at the genetic makeup and real-world cancer outcomes in people exposed to the World Trade Center disaster to understand how their cancers behave and respond to treatments.
-
Meaning-Centered Psychotherapy for Mexican Patients with Advanced Cancer
A cancer center in Mexico will test a culturally adapted therapy to help Mexican patients with advanced cancer find meaning, peace, and purpose at the end of life.
-
High-specificity genome-scale cell-surface proteomics to find tumor targets
A cancer research project is trying to map all the proteins on the surface of ultra-rare sarcoma cells to find safe, targeted ways to treat them.
-
Priorities for testing and choosing combination therapies in rhabdoid tumors to guide clinical trials
A coordinated, multi-site effort will rigorously test promising drug combinations in rhabdoid tumors to identify the most promising options for future patient trials.
-
ecDNA in Cancer: Understanding and targeting circular DNA that drives tumor growth
A cancer-focused project to understand how extrachromosomal DNA helps tumors grow and resist treatment, and to develop new ways to target these mechanisms.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.