Analyzing cell types and their locations in tissues using advanced imaging techniques
Official title: Integrative analysis of spatial transcriptomics with histology images and single cells
Funded at University of Pennsylvania · NIH-10932432 · Data updated 2026-11-12
This study is exploring how different types of cells in our tissues talk to each other and work together, using special imaging tools and gene data, to help us better understand diseases and find new ways to diagnose and treat them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | September 20, 2023 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $540,739 |
| NIH project number | 5R01HG013185-02 |
| Project ID | NIH-10932432 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions affecting tissue organization and cellular interactions, such as stroke or other cerebrovascular diseases.
✕Less likely to help
Patients with conditions unrelated to tissue cellular interactions or those who do not have access to the required imaging technologies may not benefit from this research.
What this research studies
This research investigates how different cell types within tissues interact and communicate by combining advanced imaging techniques with gene expression data. It utilizes spatial transcriptomics to map the locations of cells while also analyzing histology images and single-cell RNA sequencing data. By integrating these methods, the research aims to enhance our understanding of how the spatial organization of cells affects their behavior and contributes to disease. This approach could lead to more effective diagnostic and therapeutic strategies for various conditions.
Why it matters
Potential benefit: If successful, this research could provide insights that lead to improved treatments for diseases by understanding cell interactions in their natural environments.
How similar studies have gone: Previous research has shown promise in using similar integrative approaches to enhance our understanding of cellular behavior in various diseases.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Li, Mingyao — University of Pennsylvania
- Study coordinator: Li, Mingyao
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.