Analyzing best practices for testing fluid samples from lung cancer patients
Comprehensive Analysis of Best Practices for Clinical Testing of Malignant Pleural Effusion Specimens
This study is looking at ways to make it easier for people with advanced cancer and fluid buildup in their lungs to get important genetic information about their tumors, using a simple procedure that removes the fluid, so doctors can make better treatment choices.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-10920388 on NIH RePORTER |
What this research studies
This research focuses on patients with advanced cancers who develop malignant pleural effusions (MPEs), which are fluid collections that can contain cancer cells. The study aims to improve diagnostic methods by evaluating how thoracentesis, a procedure to remove this fluid, can be optimized for molecular testing. By analyzing the cell-free DNA found in these fluid samples, the research seeks to provide a less invasive and more efficient way to gather genetic information about tumors, potentially leading to better treatment decisions.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with advanced cancer who are experiencing malignant pleural effusions.
Not a fit: Patients without malignant pleural effusions or those with early-stage cancers may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic accuracy and treatment options for patients with advanced cancers.
How similar studies have performed: Previous research has shown promise in using cell-free DNA from other sources for molecular testing, indicating potential success for this novel approach.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Devine, Walter Patrick — University of California, San Francisco
- Study coordinator: Devine, Walter Patrick
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.