Alzheimer’s Disease Biomarkers and Trial Readiness Network (ADNI4)
Official title: Alzheimer's Disease Neuroimaging Initiative (ADNI4)
Funded at Northern California Institute/res/edu · NIH-11395192 · Data updated 2026-11-12
A large NIH-supported effort to collect and share biomarkers and data so future Alzheimer’s trials can be planned faster and more accurately.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northern California Institute/res/edu NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | September 30, 2004 |
| Project end | July 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $26,866,193 |
| NIH project number | 5U19AG024904-19 |
| Project ID | NIH-11395192 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are individuals at elevated risk for dementia or those who have other AD biomarkers and are willing to participate in long-term follow-up and data sharing.
✕Less likely to help
Patients without elevated risk or who do not participate in longitudinal biomarker collection may see limited direct benefit.
What this research studies
ADNI4 focuses on validating biomarkers for Alzheimer’s disease and improving recruitment of people at higher risk for dementia. The project will maintain and expand digital data, biofluid, genetic, and brain imaging resources, while following participants from prior ADNI studies. It also aims to recruit more individuals with elevated dementia risk and to deploy digital and in-person support to build a rich, accessible dataset for researchers and trial designers. By sharing findings and samples widely, ADNI4 helps accelerate the development of effective therapies for Alzheimer’s disease.
Why it matters
Potential benefit: If successful, this work could speed the development of new, better-targeted Alzheimer’s treatments and improve trial design so effective therapies reach patients sooner.
How similar studies have gone: ADNI has a long track record of contributing to major advances, including informing trial designs and approvals in the field.
Where this research is happening
-
Northern California Institute/res/edu
San Francisco, United States Active
Researchers
- Principal investigator: Weiner, Michael W — Northern California Institute/res/edu
- Study coordinator: Weiner, Michael W
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.