Altered blood flow in the brain as a path to preventing Alzheimer’s disease
Official title: Altered cerebral blood flow as an early modifiable contributor to Alzheimer’s disease and related dementias
Funded at Hebrew Rehabilitation Center for Aged · NIH-11431491 · Data updated 2026-11-12
This grant studies whether changing cerebral blood flow can help prevent Alzheimer’s disease and related dementias in adults.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Hebrew Rehabilitation Center for Aged NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 17, 2026 |
| Project end | May 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $655,883 |
| NIH project number | 1R01AG103824-01 |
| Project ID | NIH-11431491 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with or at risk for Alzheimer’s disease and related dementias, especially those with hypertension or vascular risk factors.
✕Less likely to help
People without risk factors or those not eligible for brain imaging and longitudinal follow-up may not directly benefit.
What this research studies
Researchers will follow adults 21 and older to see how brain blood flow changes over time and whether these changes relate to early brain changes linked to dementia. The project builds on prior findings that controlling blood pressure may affect brain blood flow and dementia risk, aiming to identify long-term factors that modulate blood flow and how this connects to dementia biology. The study could lead to new early detection methods and preventive strategies that complement existing treatments. Participants may undergo brain imaging, health assessments, and blood pressure monitoring as part of the study timeline.
Why it matters
Potential benefit: If successful, this work could pave the way for earlier detection and prevention strategies for Alzheimer’s disease and related dementias by targeting brain blood flow.
How similar studies have gone: Previous studies show that better blood pressure control can slow brain changes linked to dementia, but long-term CBF trajectories and early prevention remain to be clarified.
Where this research is happening
-
Hebrew Rehabilitation Center for Aged
Boston, United States Active
Researchers
- Principal investigator: Ma, Yuan — Hebrew Rehabilitation Center for Aged
- Study coordinator: Ma, Yuan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.