Aiming to Cure HIV by Boosting Early Immune Response and Clearing Hidden Cells
Official title: Delaney AIDS Research Enterprise to Cure HIV
Funded at University of California, San Francisco · NIH-11515078 · Data updated 2026-11-12
Researchers are testing a combination approach in people to reduce hidden HIV reservoirs while ART is ongoing and to help control the virus if treatment is stopped.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | August 16, 2021 |
| Project end | May 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $4,998,395 |
| NIH project number | 4UM1AI164560-06 |
| Project ID | NIH-11515078 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with HIV who are on ART and undergoing planned strategies to study viral rebound and immune responses.
✕Less likely to help
People not on ART or those unwilling to participate in immune/early-rebound studies may not benefit.
What this research studies
The project seeks to coordinate a strong early immune response to prevent HIV rebound when ART is interrupted, while also making infected cells more visible to the immune system for clearance. It will study immune and viral features in people to identify how persistence happens and how to interrupt it. The team plans to test therapeutic strategies that make infected cells more susceptible to the body’s natural defenses, aiming for durable remission without ongoing therapy.
Why it matters
Potential benefit: If successful, this work could move toward lasting HIV remission and reduce dependence on continuous ART.
How similar studies have gone: Earlier findings show that combining immune modulation with strategies to expose infected cells can reduce reservoirs, but results in humans are still emerging.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Deeks, Steven Grant — University of California, San Francisco
- Study coordinator: Deeks, Steven Grant
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.