A treatment to prevent heart block in babies by blocking IgG recycling during pregnancy

Who could benefit from this research

What this research studies

This study focuses on pregnant people at risk for having babies with cardiac neonatal lupus due to autoantibodies. By inhibiting the FcRn receptor, the project seeks to reduce pathogenic IgG levels that reach the fetus, potentially preventing irreversible heart block. The research builds on prior findings of autoantibodies linked to heart damage and uses maternal treatment to shield fetal heart development. Participants would be monitored for safety and fetal outcomes through pregnancy and after birth.

Why it matters

Where this research is happening

• New York University School of Medicine
  New York, United States Active

Researchers

• Principal investigator: Buyon, Jill P — New York University School of Medicine
• Study coordinator: Buyon, Jill P

Related research

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About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.