A new way to calm brain activity in Alzheimer's disease
Official title: A novel strategy to reverse neural hyperexcitability in Alzheimer's disease
Funded at Colorado State University · NIH-11453659 · Data updated 2026-11-12
A研究 project tests a new approach to reduce excessive brain activity in the hippocampus for people with Alzheimer's disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Colorado State University NIH-funded |
| Lab location | 1 site (Fort Collins, United States) |
| Project start | September 15, 2026 |
| Project end | June 30, 2031 |
| Funding year | 2026 |
| Award (this year) | $633,758 |
| NIH project number | 1R01AG099117-01A1 |
| Project ID | NIH-11453659 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults diagnosed with Alzheimer’s disease or mild cognitive impairment linked to AD who may benefit from interventions that modulate hippocampal activity.
✕Less likely to help
Patients without AD-related hippocampal hyperexcitability or those not eligible for research participation may not benefit.
What this research studies
This project focuses on how controlling excessive activity in the hippocampus might help protect memory and slow decline in Alzheimer’s disease. Researchers will study specific brain cell types that control inhibition and how the disease changes their function. The goal is to identify targeted ways to boost inhibition in the hippocampus to support cognitive function and potentially modify disease progression. The work combines animal models and human-relevant insights to pinpoint which inhibitory cells to strengthen. Results could point to new therapeutic strategies that comfort hippocampal networks and support daily thinking.
Why it matters
Potential benefit: If successful, the research could lead to treatments that reduce brain hyperactivity and help preserve memory in people with Alzheimer’s.
How similar studies have gone: Previous work suggests targeting hippocampal inhibition can influence cognitive outcomes in AD models, with ongoing exploration of subtype-specific effects.
Where this research is happening
-
Colorado State University
Fort Collins, United States Active
Researchers
- Principal investigator: Kim, Seonil — Colorado State University
- Study coordinator: Kim, Seonil
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.