A new method for diagnosing blood cancers using advanced genomic techniques
Official title: Clinical validation of Duoseq, a Swiss army knife genomic approach to diagnosis of blood cancers
Funded at Data Driven Bioscience INC · NIH-11066761 · Data updated 2026-11-12
This study is testing a new method called Duoseq that combines DNA and RNA testing to help doctors quickly and accurately diagnose blood cancers, making it easier for patients to get the answers they need.
Quick facts
| Grant type | Sbir 1 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Data Driven Bioscience INC NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | January 1, 2025 |
| Project end | April 4, 2025 |
| Funding year | 2025 |
| Award (this year) | $300,682 |
| NIH project number | 1R43CA298055-01 |
| Project ID | NIH-11066761 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals undergoing diagnostic testing for blood cancers.
✕Less likely to help
Patients with non-blood-related cancers or those who do not require genomic testing may not benefit from this research.
What this research studies
This research focuses on the clinical validation of Duoseq, a novel approach that combines DNA and RNA sequencing into a single workflow for diagnosing blood cancers. By streamlining the complex processes involved in traditional cancer diagnostics, Duoseq aims to provide faster and more accurate results. The method includes bioinformatics software that interprets genetic data directly from the sequencer, allowing for comprehensive analysis of mutations and gene expression. This could significantly reduce the time and complexity involved in diagnosing blood cancers, making it more accessible for patients.
Why it matters
Potential benefit: If successful, this research could lead to quicker and more accurate diagnoses for patients with blood cancers.
How similar studies have gone: Other research has shown promise in using integrated genomic approaches for cancer diagnosis, indicating that this method could be a significant advancement.
Where this research is happening
-
Data Driven Bioscience INC
Durham, United States Active
Researchers
- Principal investigator: Happ, Lanie Elizabeth — Data Driven Bioscience INC
- Study coordinator: Happ, Lanie Elizabeth
Related research
Other NIH-funded projects on the same topics.
-
Duoseq: a quick, all-in-one genetic test for lymphoma diagnosis
A single, streamlined sequencing approach called Duoseq could speed up and simplify diagnosing lymphomas by reading both DNA and RNA from one workflow.
-
Duoseq — one test to find DNA and RNA changes in lymphoma
Testing whether a single combined DNA-and-RNA sequencing test (Duoseq) can quickly find the genetic changes doctors use to diagnose and guide treatment for people with lymphoma.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.