Duoseq: a quick, all-in-one genetic test for lymphoma diagnosis
Official title: Validation of Duoseq as a Genomic Swiss Army Knife for the Diagnosis of Lymphomas
Funded at Data Driven Bioscience INC · NIH-11412715 · Data updated 2026-11-12
A single, streamlined sequencing approach called Duoseq could speed up and simplify diagnosing lymphomas by reading both DNA and RNA from one workflow.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Data Driven Bioscience INC NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | January 1, 2025 |
| Project end | August 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $1,022,841 |
| NIH project number | 5R44CA298055-03 |
| Project ID | NIH-11412715 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with suspected or confirmed lymphoma who need molecular diagnostic information.
✕Less likely to help
Patients not undergoing lymphoma diagnostics or those outside the clinical decision workflow may not benefit.
What this research studies
This project focuses on making genomic testing for lymphomas faster and easier by combining DNA and RNA sequencing into one streamlined process. It also includes user-friendly software that automatically analyzes results at the sequencing instrument, giving doctors key mutation, copy number, and expression information. The goal is to shorten turnaround times and reduce the complexity of interpreting results so that labs can more reliably integrate molecular data into patient care. The work centers on a real-world diagnostic pathway for lymphoma patients, aiming to fit into routine pathology workflows.
Why it matters
Potential benefit: If successful, patients could receive accurate, comprehensive molecular diagnoses faster, guiding personalized treatment decisions.
How similar studies have gone: Other dual DNA/RNA approaches exist, but Duoseq aims to integrate sequencing and analysis into a single workflow with faster turnaround.
Where this research is happening
-
Data Driven Bioscience INC
Durham, United States Active
Researchers
- Principal investigator: Happ, Lanie Elizabeth — Data Driven Bioscience INC
- Study coordinator: Happ, Lanie Elizabeth
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.